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Our Vision

  • Improving the diagnosis, prevention, and treatment of heart disease through "omics" (such as genetics, genomics, proteomics, transcriptomics), environmental and stem cell based research to identify the cause of disease and find new ways to treat patients with heart disease. 
  • Expediting scientific discovery through multi-centre participation and sharing of resources, knowledge and expertise to perform population-based studies
  • Translation of research findings to the bedside through the creation of a multi-disciplinary research network of basic and clinical scientists, physicians, geneticists, epidemiologists, statisticians with strong institutional, private and industry support to expedite clinical applications of research findings.
     

Funding Sources:

The Ted Rogers Centre for Heart Research

Labatt Family Heart Centre Development Funds

Project support provided by:
The Centre for Applied Genomics (Steve Scherer, Peter Ray, Jo-Anne Herbrick, Carol Ann Ryan)
Research IT (Wayne Arnold)
Information Technology (Shirley Wang, Rooma Vaidya, Richard Child)
Heart Centre Executive Committee (Andrew Redington, Glen Van Arsdell, Stephen Schwartz, Karen Kinnear, Erwin Oeschlin, Janet Rossant)
Ontario Human Induced Pluripotent Stem Cell Facility (James Ellis, William Stanford, Janet Rossant)

 

Finding a Cause

Genes

Genes are contained in DNA, the blueprint of life that contains the genetic instructions used in the development and functioning of all living organisms.  The role of DNA is to store information about ourselves over a long period of time.  Just like a book that contains many chapters and each chapter tells a deeper and deeper story, our DNA is much like a book telling a similar story of ourselves.  The segments of our DNA carry our genetic information called genes.  

The Heart Centre Biobank has collected DNA (blood, saliva, tissue) to assist in providing the answers to:

  • Identifying the genetic causes of disease
  • Identifying genes that influence outcomes of disease
  • Identifying genes that influence the response to therapy (pharmacogenomics)
  • Gene-environment interactions

Environment

Environmental factors can cause heart disease  and influence outcomes.  The Heart Centre Biobank studies environmental factors that cause cause heart disease during an individual’s lifetime and aims to find ways to prevent the damaging effects of the environment on the young heart.

Skin

The Heart Centre Biobank collects and banks skin cells.  These skin cells can be reprogrammed to form stem cells known as induced pluripotent stem cells (iPSC).  These iPS cells can be differentiated to form virtually any cell type in the body!  Once these cell types are formed the process of growth can be observed from early life onwards.  These cells can be used for:
1.  Disease modeling
2.  Drug screening and drug discovery
3.  Transplantation in the future